Teste Repositóri
2014-01-01
Resultados de pesquisa
Foram encontrados 1.778 registos.
BACKGROUND: Citicoline is approved in some countries for the treatment of acute ischaemic stroke. The drug has shown some evidence of efficacy in a pooled analysis. We sought to confirm the efficacy of citicoline in a larger trial.
METHODS: We undertook a randomised, placebo-controlled, sequential trial in patients with moderate-to-severe acute ischaemic stroke admitted at university hospitals in Germany, Portugal, and Spain. Using a centralised minimisation process, patients were randomly assigned in a 1:1 ratio to receive citicoline or placebo within 24 h after the onset of symptoms (1000 mg every 12 h intravenously during the first 3 days and orally thereafter for a total of 6 weeks [2×500 mg oral tablets given every 12 h]). All study participants were masked. The primary outcome was recovery at 90 days measured by a global test co...
A proporção de imigrantes nos concelhos de Amadora e Sintra atinge um dos valores mais elevados do país. A equidade na
prestação de cuidados tem sido demonstrada como factor de redução das disparidades na saúde que determina a morbilidade
e a mortalidade decorrentes da assimetria das populações.
Objectivos do estudo – Definir a prevalência dos filhos de imigrantes dos concelhos de Amadora e Sintra; analisar as famílias quanto ao país de origem, integração e procura dos serviços de saúde; avaliar as crianças nos primeiros meses de vida quanto à morbilidade e mortalidade; relacionar as características do contexto físico e social com a saúde/doença.
Metodologia – A população estudada é constituída por 1979 nados-vivos e 10 nados-mortos, cujo nascimento ou admissão
na sala de partos ocorreu no Hospital Fernando Fonseca (HFF).
Resulta...
INTRODUCTION: Group B streptococci (GBS) are transmitted from the mother to the newborn. Prevention of neonatal infection is achieved by intrapartum prophylaxis given to mothers colonized with GBS at 35 to 37 weeks of pregnancy.
MATERIALS AND METHODS: Liquid biphasic Granada medium (LB) and instant liquid biphasic Granada medium (ILB) were evaluated for GBS detection. Vaginal swabs obtained from 300 women were inoculated onto LB or ILB, or onto Todd-Hewitt broth and analyzed with the ATB system (comparison method).
RESULTS: Prevalence of GBS was 20% (61/300). LB and Todd-Hewitt with ATB detected GBS in 20% of women, and ILB in 19% of women. No growth was observed at four hours in any of the media studied. At 10 h and 14 h, identification of GBS was possible in 43/300 (14%) and 53/300 (18%) of ILB cultures, respectively, and in 32/300...
A hepatite C constitui, actualmente, um grave problema de saúde pública. Estima-se que existam, em todo o mundo, 180 milhões de pessoas com infecção crónica por vírus da hepatite C (VHC) e que a sua prevalência na população portuguesa varie entre 1 e 1,5%.
Em Portugal, não existem normas de orientação actualizadas de tratamento, nem recomendações para o diagnóstico e acompanhamento dos doentes com VHC e, em particular, para os UDEVs.
O presente artigo reúne informação de consenso relativa à de prática clínica e propõe algumas orientações para o acompanhamento e acessibilidade ao tratamento dos doentes toxicodependentes com infecção crónica por VHC, em Portugal.
Nevirapine (NVP) is a non-nucleoside reverse transcriptase inhibitor used against human immunodeficiency virus type-1 (HIV-1), mostly to prevent mother-to-child HIV-1 transmission in developing countries. Despite its clinical efficacy, NVP administration is associated with a variety of toxic responses that include hepatotoxicity and skin rash. Although the reasons for the adverse effects of NVP administration are still unclear, increasing evidence supports the involvement of metabolic activation to reactive electrophiles. In particular, Phase II activation of the NVP metabolite 12-hydroxy-NVP is thought to mediate NVP binding to bionucleophiles, which may be at the onset of toxicity. In the present study, we investigated the nature and specific locations of the covalent adducts produced in human serum albumin and human hemoglobin by re...
A granulomatose de Wegener corresponde a uma
vasculite sistémica com atingimento das artérias de pequeno e médio calibre, em particular das vias aéreas superiores e inferiores e do rim, incluindo-se
no diagnóstico diferencial das síndromas pulmão-rim.
Os AA apresentam o caso clínico de uma senhora de 59 anos, internada na Unidade de Cuidados Intensivos Polivalente (UCIP) do Hospital Fernando da Fonseca com um quadro de insuficiência respiratória, hemoptises e insuficiência renal. Descreve-se o estudo etiológico desta situação, concluindo tratar-se de um caso de granulomatose de Wegener.
A propósito deste caso são discutidos aspectos relevantes do diagnóstico, terapêutica e seguimento destes doentes.
Posterior reversible encephalopathy syndrome is an increasingly recognised clinico-radiological entity, associated with several medical conditions (such as systemic arterial hypertension) and characterised
by seizures, altered mental status, headaches, and visual symptoms. Magnetic resonance imaging is a key component in this diagnosis, with hyperintense foci in T2-weighted images, corresponding to vasogenic oedema. The pathophysiology is not fully understood but probably involves
loss of auto-regulation of cerebral vasculature or endothelial dysfunction or both. A 56-year-old male, suffering from a gastro-intestinal stromal tumour with hepatic metastasis resistant to imatinib,
on therapy with sunitinib, came to the Emergency Department because of headaches, hallucinations, and loss of vision. There was no previous history of high b...
Background: The cerebellum has traditionally been regarded as an organ of motor coordination. However, the importance of the cerebellum in psychiatric disorders, behavior, and cognition is increasingly
being recognized. There is no consensus concerning treatment of schizophrenia-like psychosis after cerebellar pathology. Reports describe the use of several antipsychotics, either alone or in combination with antidepressants or lithium. Clozapine is used for the treatment of
refractory schizophrenia, but there are no reports of its use in the abovementioned
situation.
Case Presentation: We report the case of a 20-year-old woman who developed a schizophrenia-like psychosis after rupture of arteriovenous malformation at 13 years of age. The psychotic symptoms proved to be
resistant to treatment, and several psychopharmacological schem...
