Teste Repositóri
2014-01-01
Resultados de pesquisa
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Aflatoxins (AF) and ochratoxin A (OTA) are frequent contaminants of foodstuff and low doses of these mycotoxins have
been shown to co-occur in baby foods. Our objective was to investigate whether a combined intake of AFM1 and OTA
could alter the cytotoxic and genotoxic effects of the single mycotoxins. These effects were assessed by the Neutral Red
and the Comet assays, following exposure of Caco-2 cells to individual and combined doses of the two mycotoxins. A
dose-dependent cytotoxic response was observed for OTA, whereas AFM1 was cytotoxic only at the highest dose (10BM).
Among the several combinations of OTA (2.5, 5 and 10BM) and AFM1 (0.5, 1, 2.5, 5 and 10BM) tested for cytotoxicity,
some displayed interactive effects. Noteworthy, combination of 2.5 BM of OTA and 0.5 BM of AFM1, significantly increased
the cytotoxicity, as ...
Relatório de actividades: 1 Agosto 2010-31 Julho 2011
The research leading to these results has received funding from the European Community’s Seventh Framework Programme (FP7/2007-2013) under grant agreement n.º 227118.
The research leading to these results has received funding from the European Community’s Seventh Framework Programme (FP7/2007-2013) under grant agreement n.º 227118.
Relatório de Actividades: Outubro 2010-Outubro 2011
This study was funded by the research project PIC/IC/82957/2007 from “Fundação para a Ciência e a Tecnologia” (FCT)
The research leading to these results has received funding from the European Community’s Seventh Framework Programme (FP7/2007-2013) under grant agreement n.º 227118.
