Boletim informativo NEPS
Universidade do Minho. Instituto de Ciências Sociais. Núcleo de Estudos de População e Sociedade
2001-11-01
Resultados de pesquisa
Foram encontrados 131 registos.
Tese de doutoramento em Ciências (ramo de conhecimento em Matemática)
ln the north-west of Portugal, the quaternary glaciation hadn't only reached the mountains of Gerês and Peneda. Also in Cabreira mountain, southward and with low altitude, forms and deposits with origin in the quaternary cold are remarked, even than in a smaller number and of a smaller dimension. This article tries to point out the sheltered character of the glaciation in the culminant massif of Cabreira mountain, as well as to distinguish the two kinds of landscapes present there, derived from an intense gelifraction (slopes with cryoclastic debris) and from glacial morphogenesis.
Poster apresentado na XXVII Reunião Científica Anual da SPODF. Figueira da Foz, 23-25 Abril 2015
Purpose Accumulation of methylglyoxal (MGO) in retinas of diabetic rats has been implicated in the formation of acellular capillaries, suggesting an important role for MGO in the vascular dysfunction observed in diabetes. In this study, we hypothesize that increased levels of MGO in retinal pigment epithelium (RPE) cells disturbs the balance VEGF/Ang2 secreted to the extracellular milieu, promoting apoptotis and low proliferation of endothelial cells. Methods ARPE19 cells were subjected both to hypoxia and MGO, two main features of diabetic retinopathy (DR). The levels of VEGF and Ang2 secreted into the culture medium were assessed by ELISA. Retinal endothelial cells were subsequently treated with the pre-conditioned media of the ARPE19 cells, as well as with different ratios of VEGF and Ang2 recombinant proteins. Apoptotic cell death ...
Purpose Accumulation of damaged or abnormal proteins is cytotoxic and is causally related to various age-related diseases, including cataract. The objective of this study is to investigate the effect of 19S regulatory complexes on the fate of damaged proteins. Methods The denaturation of firefly luciferase (a model protein) was performed at 43°C during 10 min in the presence of Hsp90 and denaturation of luciferase was monitored by the loss of its enzymatic activity. Luciferase activity in the cells was determined to monitor the refolding of denatured luciferase at 30°C in the presence or absence of ubiquitination system. Results The data showed that heat-denatured luciferase was preferentially ubiquitinated and degraded by the UPP as compared with the native form. Inhibition of the ubiquitination or proteolysis enhanced renaturation. T...
A questão do tempo de antibioterapia na meningite bacteriana é um assunto controverso. Os esquemas de antibioterapia têm variado ao longo do tempo bem como os critérios usados para a determinação da sua duração ideal. Os autores efectuaram uma revisão histórica sobre esta questão e, concomitantemente, reuniram a evidência de estudos recentes sobre esta temática, salientando alguns aspectos a ter em consideração na interpretação dos resultados, particularmente o desenho dos estudos e as inerentes questões demográficas e epidemiológicas. A investigação sobre esta questão, com resultados estatisticamente significativos, é relativamente recente sendo que a maior parte do conhecimento obtido é sobretudo baseado na experiência adquirida ao longo dos tempos. O paradigma da investigação actual, no que diz respeito à antibioterapia nas situaçõe...
The seed is an important production factor in the potato crop since the seed-tuber has a high price cost in Portugal, where almost the seed is imported. On the other hand, the mean national harvest is low. 15 Mg/ha (FAO, 2005), subjected to adverse environmental conditions, particularly the high temperatures during the cropping season (Rodrigues, 2000).
O Lab2PT- Laboratório de Paisagens, Património e Território (AUR/04509) é financiado pela FCT através de fundos nacionais e quando aplicável cofinanciamento do FEDER, no âmbito dos novos acordos de parceria PT2020 e COMPETE 2020 – POCI-01-0145-FEDER-007528. O grupo de investigação CULXEO é financiado pela "Xunta de Galicia" através do programa “Consolidación e estructuración de unidades de investigación competitivas — Grupo de potencial de crecimiento” (GPC2015/024).
